Image Processing Quality Analysis for Particle Based Peptide Array Production on a Microchip

Highly complex microarray systems based on combinatorial synthesis techniques are in wide-spread use in biological, medical and pharmaceutical research Chee et al. (1996); Cretich et al. (2006); Debouck & Goodfellow (1999). Two prominent examples are micro arrays for the artificial synthesis of arbitrary DNA sequences out of nucleic acids Heller (2002) and peptide synthesis out of amino acids Beyer et al. (2007); Templin et al. (2003). In the case of DNA arrays, these experiments mostly focus on gene identification or gene expression profiling to determine the effects of single genes on cellular evolution. Peptide arrays aim at understanding interactions of peptides with other molecules. As sequences in proteins, peptides are involved in the regularisation of biological activity.